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	<title>Comments for Joseph F. Clark, Ph.D.</title>
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	<link>http://www.josephfclark.com/blog</link>
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		<title>Comment on The Mayo Clinic does not care if it dispenses WRONG information by Glen</title>
		<link>http://www.josephfclark.com/blog/?p=1143&#038;cpage=1#comment-2100</link>
		<dc:creator>Glen</dc:creator>
		<pubDate>Sun, 26 Aug 2012 17:47:24 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1143#comment-2100</guid>
		<description>If you think they&#039;re wrong on creatine, you should look at the advice they give Type II diabetics...

It&#039;s the same advice pharmaceutical companies give diabetics... All research shows a low-carb ketogenic diet that&#039;s complete in essential nutrients will give the best results in glycemic control, weight-loss, cholesterol ratio and triglycerides, but mayoclinic.com states the complete opposite, and locks comments when people post otherwise.</description>
		<content:encoded><![CDATA[<p>If you think they&#8217;re wrong on creatine, you should look at the advice they give Type II diabetics&#8230;</p>
<p>It&#8217;s the same advice pharmaceutical companies give diabetics&#8230; All research shows a low-carb ketogenic diet that&#8217;s complete in essential nutrients will give the best results in glycemic control, weight-loss, cholesterol ratio and triglycerides, but mayoclinic.com states the complete opposite, and locks comments when people post otherwise.</p>
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		<title>Comment on Discovery of a treatment for one of the causes of Autism Spectrum Disorder: Creatine transporter deficiency by Eduardo Pizarro</title>
		<link>http://www.josephfclark.com/blog/?p=1185&#038;cpage=1#comment-1933</link>
		<dc:creator>Eduardo Pizarro</dc:creator>
		<pubDate>Fri, 06 Jul 2012 11:30:13 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1185#comment-1933</guid>
		<description>hello,i´m from Portugal and i want to try to help your researches i will share with my friends in facebook!My group is &quot;Os amantes de Saturno&quot; , group of parents,medics,technicians etc ,linked whit autism!
Congratulations !</description>
		<content:encoded><![CDATA[<p>hello,i´m from Portugal and i want to try to help your researches i will share with my friends in facebook!My group is &#8220;Os amantes de Saturno&#8221; , group of parents,medics,technicians etc ,linked whit autism!<br />
Congratulations !</p>
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		<title>Comment on Discovery of a treatment for one of the causes of Autism Spectrum Disorder: Creatine transporter deficiency by Joe clark</title>
		<link>http://www.josephfclark.com/blog/?p=1185&#038;cpage=1#comment-1925</link>
		<dc:creator>Joe clark</dc:creator>
		<pubDate>Tue, 03 Jul 2012 00:48:13 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1185#comment-1925</guid>
		<description>Here is a video and interview concerning the discovery. 

http://www.wlwt.com/news/health/Discovery-offers-hope-for-some-autistic-patients/-/9837732/15376754/-/156w6l7/-/index.html?fb_comment_id=fbc_10151863556055109_33408144_10151863657765109#f8bd8e17c</description>
		<content:encoded><![CDATA[<p>Here is a video and interview concerning the discovery. </p>
<p><a href="http://www.wlwt.com/news/health/Discovery-offers-hope-for-some-autistic-patients/-/9837732/15376754/-/156w6l7/-/index.html?fb_comment_id=fbc_10151863556055109_33408144_10151863657765109#f8bd8e17c" rel="nofollow">http://www.wlwt.com/news/health/Discovery-offers-hope-for-some-autistic-patients/-/9837732/15376754/-/156w6l7/-/index.html?fb_comment_id=fbc_10151863556055109_33408144_10151863657765109#f8bd8e17c</a></p>
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		<title>Comment on A survey from the US postal Service. by Dan Macinnis</title>
		<link>http://www.josephfclark.com/blog/?p=573&#038;cpage=1#comment-1835</link>
		<dc:creator>Dan Macinnis</dc:creator>
		<pubDate>Sun, 29 Apr 2012 14:36:16 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=573#comment-1835</guid>
		<description>I trust the USPS about as much as i trust FedEx and UPS.  I have had terrible service from both private services.  I have paid exorbitant rates to have items overnighted, only to have them delivered days later.  I have had items left on my doorstep that were not supposed to be left there.  They were supposed to be accepted in person only, with a signature.  But i guess the delivery man thought that was too much bother.
I sorry you&#039;ve received bad service from the USPS, but your post sounds too much like a guy with a tea party bias...&#039;everything the feds do is done poorly&#039; and &#039;the private sector can do it better&#039;.   Well, that hasn&#039;t been my experience. (well, maybe once).</description>
		<content:encoded><![CDATA[<p>I trust the USPS about as much as i trust FedEx and UPS.  I have had terrible service from both private services.  I have paid exorbitant rates to have items overnighted, only to have them delivered days later.  I have had items left on my doorstep that were not supposed to be left there.  They were supposed to be accepted in person only, with a signature.  But i guess the delivery man thought that was too much bother.<br />
I sorry you&#8217;ve received bad service from the USPS, but your post sounds too much like a guy with a tea party bias&#8230;&#8217;everything the feds do is done poorly&#8217; and &#8216;the private sector can do it better&#8217;.   Well, that hasn&#8217;t been my experience. (well, maybe once).</p>
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		<title>Comment on News for Creatine Deficiency Syndromes by Joseph</title>
		<link>http://www.josephfclark.com/blog/?p=1171&#038;cpage=1#comment-1707</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Mon, 05 Mar 2012 02:50:19 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1171#comment-1707</guid>
		<description>Dear Abhijit Kumar,
I apologize for taking so long to get to your question. Please feel free to go to the CCHMC.org web site and make a request through http://www.cincinnatichildrens.org/research/divisions/h/genetics/default/. You can also email me directly at joseph.clark@uc.edu and I&#039;ll forward your request. We have a whole creatine research and clinical team in Cincinnati and we can help get you answers concerning your child. Please also consider joining the facebook group https://www.facebook.com/groups/127389967322193/?notif_t=group_r2j#!/groups/127389967322193/. On that group I will make sure that the group knows all the latest news and research concerning the creatine transporter deficiency. You can also talk to other parents and care givers bout their children. 
Best wishes

Joe

Joseph F. Clark, Ph.D.
Professor of Neurology
University of Cincinnati
Cincinnati OH 45267-0536
513 558 7085 - office
513 558 7009 - fax
joseph.clark@uc.edu</description>
		<content:encoded><![CDATA[<p>Dear Abhijit Kumar,<br />
I apologize for taking so long to get to your question. Please feel free to go to the CCHMC.org web site and make a request through <a href="http://www.cincinnatichildrens.org/research/divisions/h/genetics/default/" rel="nofollow">http://www.cincinnatichildrens.org/research/divisions/h/genetics/default/</a>. You can also email me directly at <a href="mailto:joseph.clark@uc.edu">joseph.clark@uc.edu</a> and I&#8217;ll forward your request. We have a whole creatine research and clinical team in Cincinnati and we can help get you answers concerning your child. Please also consider joining the facebook group <a href="https://www.facebook.com/groups/127389967322193/?notif_t=group_r2j#" rel="nofollow">https://www.facebook.com/groups/127389967322193/?notif_t=group_r2j#</a>!/groups/127389967322193/. On that group I will make sure that the group knows all the latest news and research concerning the creatine transporter deficiency. You can also talk to other parents and care givers bout their children.<br />
Best wishes</p>
<p>Joe</p>
<p>Joseph F. Clark, Ph.D.<br />
Professor of Neurology<br />
University of Cincinnati<br />
Cincinnati OH 45267-0536<br />
513 558 7085 &#8211; office<br />
513 558 7009 &#8211; fax<br />
<a href="mailto:joseph.clark@uc.edu">joseph.clark@uc.edu</a></p>
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		<title>Comment on News for Creatine Deficiency Syndromes by Abhijit Kumar</title>
		<link>http://www.josephfclark.com/blog/?p=1171&#038;cpage=1#comment-1644</link>
		<dc:creator>Abhijit Kumar</dc:creator>
		<pubDate>Fri, 10 Feb 2012 19:27:00 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1171#comment-1644</guid>
		<description>Dear Dr. Clark,
I am  suspecting Creatine Deficiency in our son who is 3 year and 9 months old. He was diagnosed Autistic at 20 month old, because of his complete lack of speech both receptive and expressive. He has very evident Mental Retardation as well.  He has ataxia, constant drooling and he cannot walk properly without falling down or run. He also has very evident pyramidal movements. At first we thought it was just his autism, but I only connected the dots now. He consistently has low creatinine in his CMP profile all the time. So, it is not possible that every time he is not well hydrated all the time that he goes in for a CBC with CMP.
We noticed that something was not right with him at 15 month old.  He has low muscle tone and still very baby like as compared to children his age. 
Could you please tell me what I need to do to get him tested at Cincinnati Children’s? Do we need to go to a Metabolic Doctor here in Chicago or a neurologist to get him the test requisition or is it possible to go directly to Cincinnati Children’s and get a doctor to see him there and do the testing at the same time.?Please help me, help my child. My son is losing time.

Please feel free to call me or email me any time.
Thanks
Abhijit Kumar
Ph:312-498-3750</description>
		<content:encoded><![CDATA[<p>Dear Dr. Clark,<br />
I am  suspecting Creatine Deficiency in our son who is 3 year and 9 months old. He was diagnosed Autistic at 20 month old, because of his complete lack of speech both receptive and expressive. He has very evident Mental Retardation as well.  He has ataxia, constant drooling and he cannot walk properly without falling down or run. He also has very evident pyramidal movements. At first we thought it was just his autism, but I only connected the dots now. He consistently has low creatinine in his CMP profile all the time. So, it is not possible that every time he is not well hydrated all the time that he goes in for a CBC with CMP.<br />
We noticed that something was not right with him at 15 month old.  He has low muscle tone and still very baby like as compared to children his age.<br />
Could you please tell me what I need to do to get him tested at Cincinnati Children’s? Do we need to go to a Metabolic Doctor here in Chicago or a neurologist to get him the test requisition or is it possible to go directly to Cincinnati Children’s and get a doctor to see him there and do the testing at the same time.?Please help me, help my child. My son is losing time.</p>
<p>Please feel free to call me or email me any time.<br />
Thanks<br />
Abhijit Kumar<br />
Ph:312-498-3750</p>
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		<title>Comment on The Mayo Clinic does not care if it dispenses WRONG information by Joseph</title>
		<link>http://www.josephfclark.com/blog/?p=1143&#038;cpage=1#comment-1084</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Tue, 26 Apr 2011 14:57:16 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1143#comment-1084</guid>
		<description>Thank you so much for responding Dr. Roger Harms. Let me help you with your investigation concerning original research. GPA is guanidino propionic acid. It is an analogue of creatine. GPA and creatine are not synonyms, they are different words for different molecules. If people read your information and conclude that GPA is creatine and eat GPA, they are not getting creatine, plus GPA leads to heart failure. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138144/?tool=pubmed.
Your synonym list actually lists more than one creatine analogue.</description>
		<content:encoded><![CDATA[<p>Thank you so much for responding Dr. Roger Harms. Let me help you with your investigation concerning original research. GPA is guanidino propionic acid. It is an analogue of creatine. GPA and creatine are not synonyms, they are different words for different molecules. If people read your information and conclude that GPA is creatine and eat GPA, they are not getting creatine, plus GPA leads to heart failure. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138144/?tool=pubmed" rel="nofollow">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138144/?tool=pubmed</a>.<br />
Your synonym list actually lists more than one creatine analogue.</p>
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		<title>Comment on The Mayo Clinic does not care if it dispenses WRONG information by Roger Harms, M.D.</title>
		<link>http://www.josephfclark.com/blog/?p=1143&#038;cpage=1#comment-1083</link>
		<dc:creator>Roger Harms, M.D.</dc:creator>
		<pubDate>Mon, 25 Apr 2011 13:59:22 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=1143#comment-1083</guid>
		<description>Dr. Clark,

We’re sorry to hear that you were disappointed in your recent experience with our health information website, MayoClinic.com, and the response you received from one of our customer service representatives. Unfortunately, the representative incorrectly stated that the database that contains supplement information is licensed from Micromedex. We do license a drug database from Micromedex, but the information that you are questioning is from a database that we license from Natural Standard. These two databases are the only two sections of content on MayoClinic.com that are licensed from external parties. 

You assert that two statements on our website are inaccurate pertaining to creatine and GPA. We’ve contacted Natural Standard and they stand by the accuracy of the information as presented. We have reviewed the questions from original research and are addressing the issue with Natural Standard who has been our trusted content provider. Mayo Clinic takes seriously assertions of erroneous or unclear information, and wants to make these points known to your readers.

We appreciate your feedback and the opportunity to evaluate not only our customer service response, but also our editorial content development standards.

Best regards,

Roger Harms, M.D., Medical Director of Content, MayoClinic.com</description>
		<content:encoded><![CDATA[<p>Dr. Clark,</p>
<p>We’re sorry to hear that you were disappointed in your recent experience with our health information website, MayoClinic.com, and the response you received from one of our customer service representatives. Unfortunately, the representative incorrectly stated that the database that contains supplement information is licensed from Micromedex. We do license a drug database from Micromedex, but the information that you are questioning is from a database that we license from Natural Standard. These two databases are the only two sections of content on MayoClinic.com that are licensed from external parties. </p>
<p>You assert that two statements on our website are inaccurate pertaining to creatine and GPA. We’ve contacted Natural Standard and they stand by the accuracy of the information as presented. We have reviewed the questions from original research and are addressing the issue with Natural Standard who has been our trusted content provider. Mayo Clinic takes seriously assertions of erroneous or unclear information, and wants to make these points known to your readers.</p>
<p>We appreciate your feedback and the opportunity to evaluate not only our customer service response, but also our editorial content development standards.</p>
<p>Best regards,</p>
<p>Roger Harms, M.D., Medical Director of Content, MayoClinic.com</p>
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		<title>Comment on A survey from the US postal Service. by mcgees.org</title>
		<link>http://www.josephfclark.com/blog/?p=573&#038;cpage=1#comment-679</link>
		<dc:creator>mcgees.org</dc:creator>
		<pubDate>Tue, 14 Dec 2010 20:36:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=573#comment-679</guid>
		<description>This is a wonderful post, and I do not think it at all inappropriate to send to the USPS.

I&#039;ve been a stamp collector for many years, which has brought me in contact with a very many postal employees, and even postal officials.  And they share many of your concerns.

One problem is that the USPS is only &lt;i&gt;partially&lt;/i&gt; privatized.  The USPS is in the position of not being able to set their own pricing or policies on any but express services, regardless of their costs, but are supposed to be self-funding.  They face a Congress that dictates essentially all of their policy and business decisions and then says &quot;but beyond that, you&#039;re free to do what you like!&quot;  If Radio Shack had a branch in Nowheresville, running at a loss for its entire operation, they&#039;d merge it with the one the next town over.  If the USPS tries it, a U.S. Congressional Representative goes to the floor and insists it stays open.  Yet they still do not receive the additional government resources and allocations that should go along with the command.  Can you imagine if the federal government tried this with, say, the TSA?

Second, postal unions are &lt;i&gt;extremely&lt;/i&gt; powerful, and even for someone as liberal as I, I think their effect is mostly harm, in allowing for the &quot;walking retired&quot; phenomenon that you describe.  If one complains about a long-term postal worker, it is basically impossible to terminate him or her.  This includes the bad apples who lie and say they attempted delivery.  By the way, this is heightened by the fact that one of the powers &lt;i&gt;not&lt;/i&gt; possessed by the union is to dictate the sort of work they are able to do: I&#039;ve known letter carriers who underwent back surgery and were still expected to carry whatever the max bag weight is (it&#039;s something like 30 - 40lb) or the max parcel weight (which is a whopping 70 lbs.)

In my experience, Express Mail service is, hands down, &lt;i&gt;the best&lt;/i&gt; parcel and express letter service in the entire courier industry.  It&#039;s expensive for the consumer, however, but not really more than overnight FedEx.  And the &lt;i&gt;reason&lt;/i&gt; for this is that express services are fully privatized.

Also, services that require a signature (especially Certified with Return Receipt, and Registered [especially International Registered]) are accepted in a court with the most trust of any form of delivery.  If you go to a judge and say &quot;I promise they got it, I left-it-at-their-door/used-a-bicycle-courier/have-proof-of-delivery-from-FedEx&quot;, &lt;b&gt;none&lt;/b&gt; of those has the trust attached as does a USPS service.

A couple of tips:

1.  Your security cam is a good idea.  When you write a letter and say that you have proof that delivery was not attempted, don&#039;t threaten that you&#039;ll write your Congressional rep, promise that you&#039;ll contact the merchant and insist they no longer ship to you USPS.  A Postmaster can make a lying letter carrier&#039;s life (unofficially) hell.  I don&#039;t know for a fact that this works better, but I think it&#039;s worth a shot.

2.  Your complaints about employees have almost no official result.  But if you have a carrier whom you &lt;i&gt;like&lt;/i&gt;, write a letter of &lt;i&gt;praise&lt;/i&gt; to the postmaster out of the office he or she works.  Here&#039;s the proper way to address it under USPS regulations, this will give it the highest chance of getting to the right desk:

&lt;blockquote&gt;
POSTMASTER
PO&#160;BOX&#160;9998
YOUR TOWN&#160;CA&#160;&#160;XXXXX-9998
&lt;/blockquote&gt;

Substitute your town, your &lt;b&gt;two letter&lt;/b&gt; state abbreviation for &quot;CA&quot;, and the proper ZIP Code for &quot;XXXXX&quot;.  Everything else remains the same.

The carrier will likely get a significant cash award (hundreds of dollars) and an official commendation in his or her file.  He or she will not know who congratulated (or complained, actually) but if you ... erm, &lt;i&gt;accidentally&lt;/i&gt; let that slip, you&#039;ll likely improve your service.  That&#039;s unofficial, and possibly unethical, and arguably reprehensible on the carrier&#039;s part -- but it&#039;s also human nature and effective social engineering.  Flies/honey/vinegar.

Hope this helps someone.</description>
		<content:encoded><![CDATA[<p>This is a wonderful post, and I do not think it at all inappropriate to send to the USPS.</p>
<p>I&#8217;ve been a stamp collector for many years, which has brought me in contact with a very many postal employees, and even postal officials.  And they share many of your concerns.</p>
<p>One problem is that the USPS is only <i>partially</i> privatized.  The USPS is in the position of not being able to set their own pricing or policies on any but express services, regardless of their costs, but are supposed to be self-funding.  They face a Congress that dictates essentially all of their policy and business decisions and then says &#8220;but beyond that, you&#8217;re free to do what you like!&#8221;  If Radio Shack had a branch in Nowheresville, running at a loss for its entire operation, they&#8217;d merge it with the one the next town over.  If the USPS tries it, a U.S. Congressional Representative goes to the floor and insists it stays open.  Yet they still do not receive the additional government resources and allocations that should go along with the command.  Can you imagine if the federal government tried this with, say, the TSA?</p>
<p>Second, postal unions are <i>extremely</i> powerful, and even for someone as liberal as I, I think their effect is mostly harm, in allowing for the &#8220;walking retired&#8221; phenomenon that you describe.  If one complains about a long-term postal worker, it is basically impossible to terminate him or her.  This includes the bad apples who lie and say they attempted delivery.  By the way, this is heightened by the fact that one of the powers <i>not</i> possessed by the union is to dictate the sort of work they are able to do: I&#8217;ve known letter carriers who underwent back surgery and were still expected to carry whatever the max bag weight is (it&#8217;s something like 30 &#8211; 40lb) or the max parcel weight (which is a whopping 70 lbs.)</p>
<p>In my experience, Express Mail service is, hands down, <i>the best</i> parcel and express letter service in the entire courier industry.  It&#8217;s expensive for the consumer, however, but not really more than overnight FedEx.  And the <i>reason</i> for this is that express services are fully privatized.</p>
<p>Also, services that require a signature (especially Certified with Return Receipt, and Registered [especially International Registered]) are accepted in a court with the most trust of any form of delivery.  If you go to a judge and say &#8220;I promise they got it, I left-it-at-their-door/used-a-bicycle-courier/have-proof-of-delivery-from-FedEx&#8221;, <b>none</b> of those has the trust attached as does a USPS service.</p>
<p>A couple of tips:</p>
<p>1.  Your security cam is a good idea.  When you write a letter and say that you have proof that delivery was not attempted, don&#8217;t threaten that you&#8217;ll write your Congressional rep, promise that you&#8217;ll contact the merchant and insist they no longer ship to you USPS.  A Postmaster can make a lying letter carrier&#8217;s life (unofficially) hell.  I don&#8217;t know for a fact that this works better, but I think it&#8217;s worth a shot.</p>
<p>2.  Your complaints about employees have almost no official result.  But if you have a carrier whom you <i>like</i>, write a letter of <i>praise</i> to the postmaster out of the office he or she works.  Here&#8217;s the proper way to address it under USPS regulations, this will give it the highest chance of getting to the right desk:</p>
<blockquote><p>
POSTMASTER<br />
PO&nbsp;BOX&nbsp;9998<br />
YOUR TOWN&nbsp;CA&nbsp;&nbsp;XXXXX-9998
</p></blockquote>
<p>Substitute your town, your <b>two letter</b> state abbreviation for &#8220;CA&#8221;, and the proper ZIP Code for &#8220;XXXXX&#8221;.  Everything else remains the same.</p>
<p>The carrier will likely get a significant cash award (hundreds of dollars) and an official commendation in his or her file.  He or she will not know who congratulated (or complained, actually) but if you &#8230; erm, <i>accidentally</i> let that slip, you&#8217;ll likely improve your service.  That&#8217;s unofficial, and possibly unethical, and arguably reprehensible on the carrier&#8217;s part &#8212; but it&#8217;s also human nature and effective social engineering.  Flies/honey/vinegar.</p>
<p>Hope this helps someone.</p>
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		<title>Comment on Helping People by Ron Tedwater</title>
		<link>http://www.josephfclark.com/blog/?p=38&#038;cpage=1#comment-511</link>
		<dc:creator>Ron Tedwater</dc:creator>
		<pubDate>Sun, 21 Nov 2010 01:26:10 +0000</pubDate>
		<guid isPermaLink="false">http://www.josephfclark.com/blog/?p=38#comment-511</guid>
		<description>Great work keep it coming</description>
		<content:encoded><![CDATA[<p>Great work keep it coming</p>
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